Neurology of Pregnancy

Normal pregnancy and successful delivery in myophosphorylase deficiency (McArdle's disease).

The progress in pregnancy of a female with myophosphorylase deficiency (McArdle's disease) is described. In spite of the increased muscular effort expended, both pregnancy and labour were normal and the muscle symptoms unchanged, suggesting that compensatory mechanisms might have operated. These possible mechanisms are discussed. Women suffering from the myopathy need not expect any deteriorati...

Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): obstetrical complications and change in seizure frequency: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society.

OBJECTIVE To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including the risk of pregnancy complications or other medical problems during pregnancy in WWE compared to other women, change in seizure frequency, the risk of status epilepticus, and the rate of remaining seizure-free during pregnancy. METHODS A 20-member committee in...

Patient page. The effect of myasthenia gravis on pregnancy and the newborn.

In this issue of Neurology, Hoff et al. evaluated women with and without MG during pregnancy. They studied the occurrence of complications during delivery in these women and the health of their babies.1 The data for the study came from the Medical Birth Registry of Norway between 1967 and 2000. The authors identified 127 births by 79 MG patients and compared delivery complications and newborn h...

Successive pregnancies in multiple sclerosis.

Intracranial venous thrombosis in the first trimester of pregnancy.

We describe a fatal case of intracranial venous thrombosis occurring in early pregnancy. Such thrombosis usually occurs in late pregnancy or the puerperium but rarely during the first trimester of pregnancy. Computerized axial tomography suggested massive cerebral venous infarction. Necropsy findings showed not only cerebral venous thrombosis but also extensive pelvic and iliac vein thromboses....

Challenges in the Treatment of Epilepsy

Epilepsy is one of the most important diseases of nervous system that involves 0.5-1% of the population. In spite of new developments in antiepileptic drugs, between 20-30% of epileptic patients can not be controlled and even those who are controlled with antiepileptic drugs suffer from their adverse events. Epileptic patients have different challenges in relation to the disease and its medicat...